1865-95-8Relevant academic research and scientific papers
Cyclialkylation of arylalkyl epoxides with solid acid catalysts
Elings, Jacob A.,Downing, Roger S.,Sheldon, Roger A.
, p. 837 - 846 (2007/10/03)
Solid acids, such as zeolites and clays, catalyse the intramolecular hydroxyalkylation (cyclialkylation) of several arylalkyl epoxides in moderate to excellent conversions and selectivities. The use of solid acids in these cyclialkylations provides a cleaner, better alternative to conventional Lewis and Bronsted acids, enabling a more facile workup of reaction mixtures and, in several cases, better selectivities.
Friedel-Crafts Cyclialkylations of Some Epoxides. 3. Cyclizations of Tertiary and Meta-Substituted Arylalkyl Epoxides
Taylor, Stephen K.,Blankespoor, Curtis L.,Harvey, Suzanne M.,Richardson, Lynell J.
, p. 3309 - 3312 (2007/10/02)
The intramolecular cyclization of aryl groups to tertiary epoxide position was investigated, and the results were used to test the applicability of Baldwin's rules to this specific class of reactions.As a probe into mechanism of reactions studied earlier, the cyclizations of some meta-substituted 1,2-epoxy-5-phenylpentanes were examined to determine positional selectivities.The data obtained were compared with those of other studies, and comments are made on the reaction mechanism.
