186508-95-2 Usage
Uses
Used in Pharmaceutical Industry:
(4S,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester is used as an intermediate in the preparation of Atorvastatin 10-Trans (Atorvastatin Impurity AT10), a key component in the synthesis of Atorvastatin, a widely prescribed cholesterol-lowering drug. Its chiral nature and specific functional groups make it a valuable building block for the development of pharmaceutical compounds.
As a chiral intermediate, (4S,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester can be employed in the synthesis of various enantioselective reactions, contributing to the production of enantiomerically pure compounds with potential therapeutic applications. Its versatility in chemical transformations and its ability to form stable derivatives make it a promising candidate for further exploration in the pharmaceutical field.
Check Digit Verification of cas no
The CAS Registry Mumber 186508-95-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,5,0 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 186508-95:
(8*1)+(7*8)+(6*6)+(5*5)+(4*0)+(3*8)+(2*9)+(1*5)=172
172 % 10 = 2
So 186508-95-2 is a valid CAS Registry Number.
186508-95-2Relevant academic research and scientific papers
Synthesis of some impurities and/or degradation products of atorvastatin
Stach, Jan,Havlicek, Jaroslav,Placek, Lukas,Radl, Stanislav
, p. 229 - 246 (2008/12/22)
Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl) pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)-and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
