186542-63-2

Upstream product

• 57009-72-0 2-(3,5-dimethoxy-phenyl)-1,3-dithiane 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 2746-25-0 p-Methoxybenzyl bromide 
• 1003840-76-3 3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-3-oxo-propionic acid methyl ester 
• 186542-61-0 2-(3,5-dimethoxyphenyl)-2-(4-methoxybenzyl)-1,3-dithiane 

Downstream Products

• 1003857-12-2 N-[1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethylidene]-N'-tosylhydrazine 
• 153139-20-9 (+/-)-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanol 

Relevant academic research and scientific papers

Nazarov cyclization of divinyl and arylvinyl epoxides: Application in the synthesis of resveratrol-based natural products

New variation in the Nazarov cyclization has been developed by preparing divinyl and arylvinyl epoxides as pentadienyl cation precursors for the first time. Highly substituted cyclopentadienes, hydrindienes, and indenes were synthesized to demonstrate the compatibility of this reaction with substrates bearing a variety of substitutions and having different types of epoxides. Application of this method in the synthesis of resveratrol-based natural products was also demonstrated.

Process for the preparation of polyhydroxylated stilbenes via claisen condensation

The invention realates to a Process for the preparation of resveratrol, comprising the steps of a) reaction of a compound according to formula I with a compound according to formula II to form a compound according to formula III b) conversion of the compound according to formula III to a compound according to formula IV and, if necessary, c) deprotection of the compound according to formula IV.

NOVEL PROCESS FOR THE SYNTHESIS OF (E)-STILBENE DERIVATIVES WHICH MAKES IT POSSIBLE TO OBTAIN RESVERATROL AND PICEATANNOL

A subject-matter of the present invention is a novel process for the synthesis of (E)- stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.

Enrichment, characterization and absolute configuration of the enantiomers of 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanol

The racemate and enriched enantiomers of 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanol have been obtained via reduction of the respective ketone with LiA1H4 and with BH3 in the presence of oxazaborolidines. Enriched enantiomers were characterized by 1H NMR spectroscopy, together with the Eud-(hfbc)3 reagent, and by polarimetry. The absolute configuration was obtained by 1H and 13C NMR spectroscopy from the (S)-MTPA esters. The configuration of the esters was optimized by force-field calculation. Acta Chemica Scandinavica 1996.