Basic information

Product Name: LY 344864
Synonyms: LY 344864;LY 344864 hydrochloride;N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;LY344864 HCL
CAS NO:186544-26-3
Molecular Formula: C21H22FN3O
Molecular Weight: 351.423
EINECS: N/A
Product Categories: Inhibitors
Mol File: 186544-26-3.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 497.2°Cat760mmHg
Flash Point: 254.5°C
Appearance: /
Density: g/cm³
Vapor Pressure: 2.88E-10mmHg at 25°C
Refractive Index: N/A
Storage Temp.: Store at +4°C
Solubility: N/A
PKA: 14.12±0.40(Predicted)
CAS DataBase Reference: LY 344864(CAS DataBase Reference)
NIST Chemistry Reference: LY 344864(186544-26-3)
EPA Substance Registry System: LY 344864(186544-26-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 186544-26-3(Hazardous Substances Data)

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SDS
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186544-26-3 Usage

Uses

LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist.

Biological Activity

Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Check Digit Verification of cas no

The CAS Registry Mumber 186544-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,5,4 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 186544-26:
(8*1)+(7*8)+(6*6)+(5*5)+(4*4)+(3*4)+(2*2)+(1*6)=163
163 % 10 = 3
So 186544-26-3 is a valid CAS Registry Number.

InChI:InChI=1/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1

186544-26-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-[(6R)-6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-4-fluorobenzamide,hydrochloride

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:186544-26-3 SDS

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