186545-76-6Relevant academic research and scientific papers
S-2-naphthylmethyl thioacetimidate hydrobromide: A new odorless reagent for the mild synthesis of substituted acetamidines
Shearer, Barry G.,Oplinger, Jeffrey A.,Lee, Shuliang
, p. 179 - 182 (1997)
The development, synthesis and use of S-2-naphthylmethyl thioacetimidate hydrobromide 7 as a highly reactive reagent for the mild conversion of amines to substituted acetamidines in a nonodorous process is described.
Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine
MacCallini, Cristina,Ammazzalorso, Alessandra,De Filippis, Barbara,Fantacuzzi, Marialuigia,Giampietro, Letizia,Masella, Simona,Tricca, Maria Luisa,Amoroso, Rosa,Patruno, Antonia,Franceschelli, Sara
, p. 991 - 995,5 (2012/12/12)
A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linki
Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine
MacCallini, Cristina,Patruno, Antonia,Ammazzalorso, Alessandra,De Filippis, Barbara,Fantacuzzi, Marialuigia,Franceschelli, Sara,Giampietro, Letizia,Masella, Simona,Tricca, Maria Luisa,Amoroso, Rosa
, p. 991 - 995 (2013/01/15)
A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linki
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase
Maccallim, Cristina,Patruno, Antonia,Be?ker, Neva,Alì, Jamila Isabella,Ammazzalorso, Alessandra,De Filippis, Barbara,Franceschelli, Sara,Giampietro, Letizia,Pesce, Mirko,Reale, Marcella,Tricca, Maria L.,Re, Nazzareno,Felaco, Mario,Amoroso, Rosa
supporting information; experimental part, p. 1481 - 1485 (2009/12/26)
New acetamidines structurally related to N-(3-(aminomethyl)benzyl) acetamidine (1, W1400) were designed as inhibitors of inducible nitric oxide synthase (iNOS). Six compounds were found to be selective for iNOS over endothelial nitric oxide synthase (eNOS), and among them, the most active and selective compound was the N-benzylacetamidine 2. A docking study was also performed to shed light on the effects of the structural modifications on the interaction of the designed inhibitors with the NOS.
