186596-01-0

Basic information

• Product Name: C₅₁H₄₉Cl₆NO₁₆
• Synonyms: C₅₁H₄₉Cl₆NO₁₆
• CAS NO: 186596-01-0
• Molecular Weight: 1144.67
• Mol File: 186596-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₁H₄₉Cl₆NO₁₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₁H₄₉Cl₆NO₁₆(186596-01-0)
• EPA Substance Registry System: C₅₁H₄₉Cl₆NO₁₆(186596-01-0)

Safety Data

• Hazardous Substances Data: 186596-01-0(Hazardous Substances Data)

Upstream product

• 95603-44-4 7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III 
• 235432-37-8 (4S,5S)-2,4-diphenyl-1,3-oxazoline-5-carboxylic acid 
• 158722-22-6 (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid 

Downstream Products

• 709038-58-4 (2'S,3'S)-10-deacetyl-2'-deoxy-2'-epi-acetylmercaptopaclitaxel 
• 709038-57-3 (2'S,3'S)-3'-N-benzoylamino-2'-deoxy-2'-thioacetyl-7,10-di-(2,2,2-trichloroethyloxycarbonyl)paclitaxel 

Relevant articles and documents

Synthesis of novel thiol taxoids based on the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III: Both the syn and anti 10-deacetyl-2′-deoxy-2′-mercaptopaclitaxels

Two new kinds of docetaxel compound, with a mercapto group instead of the hydroxyl on the C13 side chain (both syn and anti), via the 7,10-di-(2,2,2- trichloroethyloxycarbonyl)-10-deacetylbaccatin III route, were synthesized. The uses of trans and cis oxazoline compounds, and their stereoselective ring-opening reactions with thiolacetic acid, were proved to be key steps.