186600-44-2Relevant academic research and scientific papers
Mucin Type Glycopeptides: Synthesis of Core 2, Core 6 and F1-α Building Blocks and Some Unexpected Reactions
Qui, Dongxu,Koganty, R. Rao
, p. 45 - 48 (1997)
Protected Core 2 and 6 and F1-α analogs were synthesized using the 4,6-diol of Tn-Ser/Thr and TF-Ser/Thr.Acetylation of glucosamine in acetic anhydride/pyridine resulted in an additional and unusual N-acetylation at the Fmoc protected amine of serine and threonine followed by β-elimination of the aglycons.Normal glucosamine acetylation was carried out at -20 deg C for 20 minutes to accomplish in synthesis of Core 2, Core 6 and F1-α as glycopeptide building blocks.
