186602-56-2

Basic information

• Product Name: Methyl-2-n-Heptyl-4-Tritylthio Acetoacetate
• CAS NO: 186602-56-2
• Molecular Weight: 488.691
• Mol File: 186602-56-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methyl-2-n-Heptyl-4-Tritylthio Acetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-2-n-Heptyl-4-Tritylthio Acetoacetate(186602-56-2)
• EPA Substance Registry System: Methyl-2-n-Heptyl-4-Tritylthio Acetoacetate(186602-56-2)

Safety Data

• Hazardous Substances Data: 186602-56-2(Hazardous Substances Data)

Upstream product

• 34914-36-8 2-(triphenylmethylthio)ethanoic acid 
• 1731-84-6 nonanoic acid methyl ester 
• 166169-07-9 N-methoxy-N-methyl-2-(tritylthio)acetamide 

Downstream Products

• 186603-04-3 2-(1-Hydroxy-2-tritylsulfanyl-ethyl)-nonanoic acid ((S)-2-cyclohexyl-1-phenethylcarbamoyl-ethyl)-amide 
• 186602-61-9 2-(1-Hydroxy-2-tritylsulfanyl-ethyl)-nonanoic acid [(S)-1-((S)-1-ethylcarbamoyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-amide 
• 186603-08-7 2-(2-Tritylsulfanyl-acetyl)-nonanoic acid ((S)-2-cyclohexyl-1-phenethylcarbamoyl-ethyl)-amide 
• 186602-65-3 2-(2-Tritylsulfanyl-acetyl)-nonanoic acid [(S)-1-((S)-1-ethylcarbamoyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-amide 

Relevant articles and documents

INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE

Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.

Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors

A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α- mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).