186602-85-7Relevant academic research and scientific papers
Malonyl α-mercaptoketones and α-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors
Campbell, David A.,Xiao, Xiao-Yi,Harris, David,Ida, Satoru,Mortezaei, Reza,Ngu, Khehyong,Shi, Lihong,Tien, David,Wang, Yongwen,Navre, Marc,Patel, Dinesh V.,Sharr, Michele A.,DiJoseph, John F.,Killar, Loran M.,Leone, Christina L.,Levin, Jeremy I.,Skotnicki, Jerauld S.
, p. 1157 - 1162 (2007/10/03)
A novel series of matrix metalloproteinase (MMP) inhibitors is described. Incorporation of a terminal α-mercaptoketone or α- mercaptoalcohol in the zinc binding domain of a series of inhibitors led to compounds exhibiting low nanomolar activity against collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
