186602-93-7

Basic information

• Product Name: 2-Amino-4-(trifluoromethyl)benzenemethanol
• Synonyms: 2-Amino-4-(trifluoromethyl)benzenemethanol;(2-amino-4-(trifluoromethyl)phenyl)methanol
• CAS NO: 186602-93-7
• Molecular Weight: 191.153
• Mol File: 186602-93-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2-Amino-4-(trifluoromethyl)benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-(trifluoromethyl)benzenemethanol(186602-93-7)
• EPA Substance Registry System: 2-Amino-4-(trifluoromethyl)benzenemethanol(186602-93-7)

Safety Data

• Hazardous Substances Data: 186602-93-7(Hazardous Substances Data)

Usage

Physical Form

White to light yellow crystalline powder

Solubility

Soluble in organic solvents like ethanol and ether

Applications

Intermediate in pharmaceutical synthesis
Intermediate in agrochemical synthesis
Intermediate in organic compound synthesis
Used in dye and pigment production

Biological/Pharmacological Studies

Investigated for potential biological and pharmacological activities

Versatile Use

Finds applications across various industries and research fields.

Upstream product

• 109466-87-7 4-(trifluoromethyl)-2-nitrobenzaldehyde 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 98-16-8 3-trifluoromethylaniline 
• 320-94-5 2-nitro-4-trifluoromethylbenzoic acid 
• 133605-27-3 (2-nitro-4-(trifluoromethyl)phenyl)methanol 
• 109134-07-8 t-butyl<3-(trifluoromethyl)phenyl>-carbamate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1396548-59-6 N-(2-formyl-5-(trifluoromethyl)phenyl)-4-methylbenzenesulfonamide 
• 450-62-4 7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline 
• 109133-94-0 tert-butyl N-(2-formyl-5-trifluoromethyl-phenyl)carbamate 

Relevant articles and documents

Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3′-quinoline] derivatives

Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3′-quinoline] derivatives. This journal is

Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives

A Pd-catalyzed, highly regioselective and stereoselective three-component domino allylic substitution/N-H carbene insertion reaction under mild conditions is described. This reaction demonstrates a wide substrate scope and satisfactory functional group tolerance, providing a broad range of allylic sulfone-containing amino acid derivatives. Moreover, DBU mediates highly diastereoselective cross-dehydrogenative coupling annulation of allylic sulfones without using peroxides or any metal oxidants. This developed protocol affords 7-membered ring heterocyclic compounds incorporating both sulfone-containing amino acid esters and one quaternary carbon center. Mechanistic studies indicate that an unusual umpolung of glycine occurred in this annulation.

Decarboxylative [4+2] Cycloaddition by Synergistic Palladium and Organocatalysis

A novel reaction based on synergistic catalysis, combining palladium- and organocatalysis has been developed. The palladium catalyst activates vinyl benzoxazinanones via a decarboxylation to undergo a [4+2] cycloaddition with iminium-ion activated α,β-uns