186653-18-9

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 96-32-2 bromoacetic acid methyl ester 
• 177944-16-0 (R)-N-(but-3-en-1-yl)-N-(α-methylbenzyl)amine 

Downstream Products

• 186653-19-0 (2R,3S)-3-Methyl-1-((R)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 420840-13-7 3-cyanomethyl-1(1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 506420-64-0 (2R,3S)-1-[(R)-1-phenylethyl]-3-[(phenylsulfanyl)methyl]pyrrolidine-2-carboxylic acid methyl ester 
• 506420-67-3 (2R,3S)-1-[(R)-1-phenylethyl]-3-[(phenylsulfonyl)methyl]pyrrolidine-2-carboxylic acid methyl ester 
• 506420-69-5 (2R,3S)-1-[(R)-1-phenylethyl]-3-[1-(phenylsulfonyl)ethyl]pyrrolidine-2-carboxylic acid methyl ester 
• 1021878-40-9 (3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-6(1H)-one 
• 180724-68-9 3-methyl proline methyl ester 
• 420840-17-1 (2R,3R)-3-Methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

(Indazol-4-YL) Hexahydropyrrolopyrrolones and Methods of Use

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein GAr, L1, Z1 and Z2 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav 1.7 and/or Nav 1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Amino-zinc-enolate carbometalation reactions: Application to ring closure of terminally substituted olefin for the asymmetric synthesis of cis- and trans-3-prolinoleucine

The amino-zinc-enolate cyclization reaction is a straightforward route for the synthesis of 3-substituted prolines. As classical intramolecular carbometalation reactions, the applicability of the addition of zinc to a double bond was limited to a substrat

Diastereoselective and Enantioselective Intramolecular Amino-Zinc-Enolate Carbometalation Reactions. A New Polysubstituted Pyrrolidines Synthesis

The amino-zinc-enolate cyclization allowed a new and straightforward route to polysubstituted pyrrolidines from simple starting materials. From this study, we have been able to determine, for the first time, the stereochemical influence of the substituents on the ring in the carbocyclization reaction. The diastereoselectivity thus obtained was explained by a chairlike amino-zinc-enolate transition state.