18667-57-7Relevant articles and documents
Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
Stefani, Christian,Al-Eisawi, Zaynab,Jansson, Patric J.,Kalinowski, Danuta S.,Richardson, Des R.
, p. 20 - 37 (2015)
Bis(thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic properties. However, their mechanism of action remains unclear. We examined the structure-activity relationships of twelve bis(thiosemicarbazones) to elucidate factors
Synthesis and Characterisation of Indium(III) Bis-Thiosemicarbazone Complexes: 18F Incorporation for PET Imaging
Venkatachalam, Taracad K.,Bernhardt, Paul V.,Pierens, Gregory K.,Stimson, Damion H. R.,Bhalla, Rajiv,Reutens, David C.
, p. 383 - 391 (2019/03/21)
Several structurally related indium chlorido complexes of bis-thiosemicarbazones were prepared, starting from the appropriately substituted bis-thiosemicarbazones, using sodium methoxide in methanol. Detailed NMR studies were conducted to assign the struc
IMAGING AGENTS
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Paragraph 0088, (2017/05/17)
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly after production, readily cross the blood-brain barrier, and may utilize a number of different radionuclides.
Heteronuclear NMR Spectroscopic Investigations of Gallium Complexes of Substituted Thiosemicarbazones Including X-Ray Crystal Structure, a New Halogen Exchange Strategy, and 18F Radiolabelling
Venkatachalam,Pierens,Bernhardt, Paul V.,Stimson,Bhalla,Lambert,Reutens
, p. 1033 - 1048 (2016/10/12)
Five thiosemicarbazone ligands have been synthesized, and their coordination chemistry with gallium was investigated. The reaction of these thiosemicarbazones with gallium chloride in alcohol solutions in the presence of a base yielded the corresponding p