18667-57-7Relevant articles and documents
Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
Stefani, Christian,Al-Eisawi, Zaynab,Jansson, Patric J.,Kalinowski, Danuta S.,Richardson, Des R.
, p. 20 - 37 (2015)
Bis(thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic properties. However, their mechanism of action remains unclear. We examined the structure-activity relationships of twelve bis(thiosemicarbazones) to elucidate factors
IMAGING AGENTS
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Paragraph 0088, (2017/05/17)
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly after production, readily cross the blood-brain barrier, and may utilize a number of different radionuclides.