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Usage

Uses

Used in Cellular and Molecular Research:
2-NBDG is used as a fluorescent glucose uptake indicator for real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry. It allows researchers to study glucose uptake in E. coli, live mammalian cells, and tumor biopsies, providing valuable insights into cellular metabolism and glucose transport mechanisms.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-NBDG can be used as a research tool to investigate the effects of various drugs on glucose uptake and metabolism. This can help in the development of new therapeutic strategies for conditions related to glucose metabolism dysregulation, such as diabetes and cancer.
Used in Diagnostic Applications:
2-NBDG can be employed in the development of diagnostic tools for detecting and monitoring glucose uptake abnormalities in various diseases. By visualizing glucose uptake in cells, it can aid in the early detection of conditions like cancer, where altered glucose metabolism is a common feature.
Used in Educational Purposes:
In academic settings, 2-NBDG can serve as an educational tool to demonstrate glucose uptake and metabolism in cells. It can be used in laboratory experiments and demonstrations to help students understand the fundamental processes of cellular metabolism and the role of glucose in cellular function.

References

1) Yoshioka?et al. (1996),?A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli; Biochim. Biophys. Acta,?1289?5 2) Yamada?et al. (2000),?Measurement of glucose uptake and intracellular calcium concentration in single, living, pancreatic beta-cells; J. Biol. Chem.,?275?22278 3) Loaiza?et al. (2003),?Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy; J. Neurosci.,?23?7337