18669-04-0Relevant academic research and scientific papers
ALLENE ETHERS FOR THE CATIONIC CYCLOPENTANNELATION
Tius, Marcus A.,Ousset, J-B.,Astrab, Donald P.,Fauq, Abdul H.,Trehan, Sanjay
, p. 923 - 924 (1989)
Only allene ethers having a group which is capable of departing as a stable cation participate successfully in the cationic cyclopentannelation reaction.
Synthesis of 3-hydroxy-1-methyl-2-(methylthio)pyrrole from methyl isothiocyanate and prop-2-yn-1-ol
Brandsma,Nedolya,Trofimov
, p. 1634 - 1636 (2000)
A methylated adduct of lithiated 1-(1-ethoxyethoxy)allene and methyl isothiocyanate undergoes intramolecular cyclization in the presence of CuBr to give 3-(1-ethoxyethoxy)-1-methyl-2-(methylthio)pyrrole. The methanolysis of the latter affords 3-hydroxy-1-methyl-2-(methylthio)pyrrole.
A convenient synthesis of 4-halo-3-(hydroxymethyl)-2,5-dihydro-1,2- oxaphospholes
Brel, Valery K.
, p. 710 - 712 (1998)
Several 5-alkyl-2-ethoxy-4-halo-3-(hydroxymethyl)-5-methyl-2-oxo-2,5- dihydro-1,2-oxaphospholes 5a-f were synthesized by a simple and efficient four-step procedure starting from propargyl alcohol.
One-Pot Synthesis of 1-(1-Alkoxyethoxy)allenes
Tarasova,Nedolya,Albanov
, p. 1831 - 1834 (2018)
A convenient one-pot procedure has been proposed for the preparation of 1-(1-alkoxyethoxy)allenes from alkoxyethenes and prop-2-yn-1-ol with the use of trifluoroacetic acid as highly efficient catalyst for the synthesis of 3-(1-alkoxyethoxy)prop-1-ynes and of the system t-BuOK–DMSO for the isomerization of the latter into allenes.
Synthesis of Cyclooctatetraenes through a Palladium-Catalyzed Cascade Reaction
Blouin, Sarah,Gandon, Vincent,Blond, Ga?lle,Suffert, Jean
supporting information, p. 7208 - 7211 (2016/07/06)
Reported is a cascade reaction leading to fully substituted cyclooctatetraenes. This unexpected transformation likely proceeds through a unique 8π electrocyclization reaction of a ene triyne. DFT computations provide the mechanistic basis of this surprizing reaction.
Direct, catalytic synthesis of carbapenams via cycloaddition/rearrangement cascade reaction: Unexpected acetylenes' structure effect
Mames, Adam,Stecko, Sebastian,Mikolajczyk, Paulina,Soluch, Magdalena,Furman, Bartlomiej,Chmielewski, Marek
supporting information; experimental part, p. 7580 - 7587 (2011/03/17)
Reactions of acetylenes derived from glyceraldehyde and propargyl aldehyde show remarkable reactivity in Kinugasa cycloaddition/rearrangement cascade process catalyzed by Cu(I) ion. Reactions proceed by formation of a rigid dinuclear copper(I) complex in which each copper ion is coordinated to one or both oxygen atoms in the acetylene molecule and to both triple bonds. It has been demonstrated that one oxygen atom can be replaced by the phenyl ring, which is able to coordinate the copper ion by the aromatic sextet. Kinugasa reactions that proceed in a high yield can also be performed in the presence of a catalytic amount of the copper salt to provide products in an acceptable yield without a decrease of diastereoselectivity.
Synthesis of 4-substituted-4-(diethylphosphono)-2-methylbuta-2,3-dien-1- oles
Brel, Valery K.
, p. 3869 - 3880 (2007/10/03)
Several 4-substituted 4-(diethylphosphono)-2-methylbuta-2,3-dien-1-oles 4a-f were synthesized by a simple and efficient three-step procedure starting from acetylene derivatives.
Propiolophenone derivatives
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, (2008/06/13)
Propiolophenone derivatives of the formula STR1 wherein R6 is hydrogen, lower alkyl or a group of the formula STR2 as well as corresponding hydroxy compounds of the formula STR3 wherein R6' is hydrogen, lower alkyl, a group of formula (a), (b), (c), (d) or (e) or a group of the formula exhibit mucosa-protective and/or gastric acid secretion-inhibiting properties, such that they can be used for the control or prevention of illnesses of the gastrointestinal tract, especially against gastric ulcers and/or duodenal ulcers.
