186704-15-4

Upstream product

• 17176-77-1 Dibenzyl phosphite 
• 186704-14-3 (R)-(2-isopropenyloxiran-2-yl)methanol 
• 26431-13-0 3-methyl-2-methylenebut-3-en-1-ol 
• 729592-74-9 1-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-3-methylbut-3-en-2-ol 
• 729592-75-0 2-isopropenylpropane-1,2,3-triol 
• 729592-76-1 1-chloro-2-(chloromethyl)-3-methylbut-3-en-2-ol 
• 729592-77-2 (S)-2-hydroxy-2-(hydroxymethyl)-3-methylbut-3-enyl acetate 
• 729592-80-7 (S)-(2-isopropenyloxiran-2-yl)methyl acetate 

Downstream Products

• 186704-13-2 ((S)-2-Hydroxy-2-hydroxymethyl-3-oxo-butyl)-phosphonic acid dibenzyl ester 

Relevant academic research and scientific papers

Chemoenzymatic formal synthesis of (S)-(-)-phosphonotrixin

Phosphonotrixin is a herbicidal antibiotic characterized by a unique structure bearing a C-P bond on an isoprene unit. The formal enantioselective synthesis of (S)-(-)-phosphonotrixin (ee=93%) in nine steps and 12% overall yield from 1,3-dihydroxyacetone

Synthesis and biological activities of phosphonothrixin

A novel herbicidal compound phosphonothrixin possessing a C-P bond, was isolated from the fermentation broth of Saccharothrix sp. ST-888. The biological activity against various weeds and total synthesis of phosphonothrixin are described herein.

Enantioselective synthesis of phosphonothrixin and its absolute stereochemistry

The synthesis of both enantiomers of phosphonothrixin is described. On the basis of optical rotation and biological activity, the natural product was determined to have S configuration.