186749-27-9

Upstream product

• 186749-25-7 5-(Benzyloxycarbonylmethyl-amino)-1-cyclopropyl-7,8-difluoro-4-oxo-1,4-dihydro-quinoline-3,6-dicarboxylic acid diethyl ester 
• 76731-85-6 β-cyclopropylaminopropionic acid ethyl ester 
• 119947-29-4 diethyl 2,4,5,6-tetrafluoroisophthalate 
• 142665-84-7 1-Cyclopropyl-5,7,8-trifluoro-4-hydroxy-1,2-dihydro-quinoline-3,6-dicarboxylic acid diethyl ester 
• 142665-85-8 1-Cyclopropyl-5,7,8-trifluoro-4-oxo-1,4-dihydro-quinoline-3,6-dicarboxylic acid diethyl ester 
• 142665-83-6 4-[Cyclopropyl-(2-ethoxycarbonyl-ethyl)-amino]-2,5,6-trifluoro-isophthalic acid diethyl ester 

Downstream Products

• 186749-29-1 6-Cyclopropyl-4,5-difluoro-3-hydroxy-9-oxo-6,9-dihydro-1H-pyrrolo[2,3-f]quinoline-2,8-dicarboxylic acid 2-benzyl ester 

Relevant academic research and scientific papers

Pyrroloquinolones and pyrazoloquinolones as potential antibacterial agents. Synthesis and antibacterial activity

Diethyl 1-cyclopropyl-5,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3,6-dicarboxylate 4 as a key-intermediate was synthesized via the Dieckmann reaction. The reaction of 4 with nucleophiles proceeded regioselectively at C-5. Facile cyclization between the C-5 and C-6 side chains of the resulting products gave novel pyrroloquinolones 10 and 12 and pyrazoloquinolones 15. They were converted into a series of cyclic amino-substituted pyrroloquinolones 17-21 and pyrazoloquinolones 22-24, and their in vitro antibacterial activities were tested. 1H-Pyrrolo[2,3-f]quinolone 17a and 2H-pyrrolo[3,4-f]quinolone 21a exhibited a potent in vitro antibacterial activity.