186758-13-4

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 

Downstream Products

• 186758-14-5 (2S,3R)-2-Acetoxy-3-bromo-3-(4-fluoro-phenyl)-propionic acid methyl ester 
• 186758-10-1 (2R,3S)-2-Acetoxy-3-azido-3-(4-fluoro-phenyl)-propionic acid methyl ester 
• 186758-11-2 (2R,3S)-3-Azido-3-(4-fluoro-phenyl)-2-hydroxy-propionic acid methyl ester 
• 143527-64-4 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 
• 154306-86-2 (4S,5R)-4-(4-Fluoro-phenyl)-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 
• 154306-85-1 methyl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-(4-fluorophenyl)propionate 

Relevant academic research and scientific papers

Synthesis of taxoids I. Regioselective Lewis acid-mediated ring-opening of aryl orthoacetates

The reaction of aryl orthoacetates with acetyl bromide readily proceeded regioselectively to afford the desirable aryl bromides in the presence of tin(II) or zinc bromide as a catalyst. The synthesis of some docetaxel derivatives is also described by using this improved process.