18676-68-1Relevant articles and documents
Copper-mediated synthesis of N-vinyl ynamides from N-vinyl carbamates
Le Fouler, Vincent,Duret, Guillaume,Bisseret, Philippe,Blanchard, Nicolas
, p. 3349 - 3352 (2018)
Ynamides are versatile 3-atoms building blocks for organic synthesis as they participate in a variety of ionic, radical and pericyclic processes. Converting ynamides into 5-atom building blocks, such as the yet unreported N-vinyl ynamides, would open new avenues in this fascinating chemistry. We describe herein our efforts towards such goal and demonstrate that the cross-coupling between N-vinyl carbamates and bromo-alkynes using copper(I) thiophene carboxylate, 1,10-phenanthroline and tBuOK in DMSO is a reactive system with an improved profile compared to the classical ynamides syntheses. The advantages and limitations of this copper-mediated reaction are discussed.
Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides
Li, Meng,Fang, Songjia,Zheng, Jia,Jiang, Huanfeng,Wu, Wanqing
supporting information, p. 8439 - 8443 (2019/10/16)
A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp2) and C(sp2)a
