186797-82-0Relevant academic research and scientific papers
A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation
Krasavin, Mikhail,Sapegin, Alexander,Dorogov, Mikhail
, p. 56 - 60 (2015/02/05)
We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
