18686-82-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Mercapto-1,3,4-thiadiazol is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be incorporated into a wide range of therapeutic agents, enhancing their efficacy and pharmacological properties.
Used in Ceftezole Thiazole:
2-Mercapto-1,3,4-thiadiazol is used as a key component in the synthesis of ceftezole thiazole, a broad-spectrum antibiotic. Its presence in the molecule contributes to the drug's effectiveness against a variety of bacterial infections, making it a valuable asset in the treatment of different medical conditions.

InChI:InChI=1/C2H2N2S2/c5-2-4-3-1-6-2/h1H,(H,4,5)

Upstream product

• 61929-24-6 2-bromo-1,3,4-thiadiazole 
• 17356-08-0 thiourea 
• 70028-72-7 C₂H₃N₂OS₂^(1-)*K⁽¹⁺⁾ 
• 56366-87-1 CH₄N₂S₂*C₆H₁₅N 
• 122-51-0 orthoformic acid triethyl ester 
• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 

Downstream Products

• 3530-72-1 2-(phenylthio)-1,3,4-thiadiazole 
• 289-06-5 1,3,4-thiadiazole 
• 156662-53-2 p-nitrobenzyl (6S,7S)-7-(4-nitrophthalimido)-8-oxo-3-<(1,3,4-thiadiazol-2-yl)thiomethyl>-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 136248-52-7 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-3-([1,3,4]thiadiazol-2-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 220430-19-3 benzhydryl (1S,5R,6S)-1-(2-p-methoxybenzyloxyethyl)-2-(1,3,4-thiadiazol-2-yl)thiomethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate 
• 220430-32-0 benzhydryl (1S,5R,6S)-1-(4-tert-butoxycarbonylaminobutyl)-2-(1,3,4-thiadiazol-2-yl)thiomethyl-6-<(1R)-1-triethylsilyloxyethyl>carbapen-2-em-3-carboxylate 
• 179034-67-4 benzhydryl 7β-(2-phenylacetamido)-3-(1,3,4-thiadiazol-2-yl)thio-3-cephem-4-carboxylate 
• 666752-72-3 2-[[(3-chlorophenyl)methyl]thio]-6-[[(1R)2-hydroxy-1-methylethyl]amino]-5-(1,3,4-thiadiazol-2-ylthio)-4-pyrimidinol 
• 752242-33-4 5-isopropoxy-3-(1,3,4-thiadiazol-2-yl-thio)benzoic acid methyl ester 

Relevant academic research and scientific papers

Efficient formation of C–S bond using heterocyclic thiones and arynes

Phenylthio heterocyclic compounds are widely used because of their diverse biological activities and medicinal prospects. Here, a facile method was reported. An arylation of 1,3,4-oxa(thia)diazol-2-thiones reacting with arynes to build C(aryl)-S bonds in the presence of CsF had good yields and excellent selectivity. The reaction was completed in short time without using expensive reagents and catalysts. Present reaction system is an efficient procedure to process phenylthio heterocyclic compounds and reveals a sustainable method and better application prospects in future organic synthesis.

Thiadiazole Which can be used as a Vulcanization Accelerator and Method for Obtaining Same

A thiadiazole of formula (I):

Cephalosporin compounds and antibacterial agents

Cephalosporin compounds of the formula (I): STR1 wherein R1 and R2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

Acylamino-cephem-carboxylic acids containing an amidino or guanidino group in the molecule

Acylamino-cephem-carboxylic acids of the formula I STR1 in which R1, R2 and R3 represent hydrogen or alkyl, R1 and R2 or R2 and R3 together may form an alkylene radical which may be substituted, X represents a single bond or NH, A represents a phenylene or thienylene radical which may be substituted, Y represents a single bond or oxygen and Z represents a 5- or 6-membered ring which may be substituted and which may be bound to an anellated ring system, and their physiologically tolerated salts and esters, a process for preparing these compounds and preparations containing them.

7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

7-[α-(2-Aminomethyl-1-cyclohexyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.

7-(3-Substituted ureido) cephalosporins

Cephalosporin compounds with 3-substituted ureido or -thioureido group at position 7 and hydrogen or heterocyclicthiomethyl groups at position 3 are prepared. These compounds are antibacterial agents.