186891-45-2

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 186891-44-1 7-[(4-Methoxy-benzyl)-(toluene-4-sulfonyl)-amino]-3-oxo-heptanoic acid methyl ester 

Downstream Products

• 186891-48-5 4-Methyl-N-[4-((4R,6S)-6-methyl-2,2-dioxo-2λ⁶-[1,3,2]dioxathian-4-yl)-butyl]-benzenesulfonamide 
• 186891-47-4 N-((5R,7S)-5,7-Dihydroxy-octyl)-4-methyl-benzenesulfonamide 
• 186891-49-6 (+)-(2S)-3-[(2S)-N-(p-toluenesulfonyl)piperidin-2-yl]propan-2-ol 
• 186891-46-3 N-((R)-5-Hydroxy-7-oxo-octyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Heterocyclisation via 1,3-Cyclic Sulfates. Asymmetric Synthesis of (+)-Sedridine

1,3-Cyclic sulfates (1b-d) participate in heterocyclisation reactions to give pyrrolidines (2b) and piperidines (2c/d). Cyclic sulfate activation, when coupled to the enantio- and diastereoselective generation of 1,3-diols, provides a synthesis of (+)-sedridine (9).