18690-82-9Relevant academic research and scientific papers
t-BuOK mediated oxidative coupling amination of 1,4-naphthoquinone and related 3-indolylnaphthoquinones with amines
Dong, Yu,Mei, Ting,Luo, Qi-Qi,Feng, Qiang,Chang, Bo,Yang, Fan,Zhou, Hong-Wei,Shi, Zhi-Chuan,Wang, Ji-Yu,He, Bing
, p. 6776 - 6780 (2021)
The transition-metal free amination of 1,4-naphthoquinone and related 3-indolylnaphthoquinones with amines, such as various (hetero)aromatic amine and aliphatic aminevia t-BuOK-mediated oxidative coupling at room temperature has been developed. This react
Aromatic amine indole naphthoquinone derivative and preparation method thereof
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Paragraph 0096-0100, (2021/06/22)
The invention relates to the technical field of organic synthesis, and discloses an aromatic amine indole naphthoquinone derivative and a preparation method thereof. The chemical structural formula is shown in the specification, in the formula, R1 is sele
Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones
Khodade, Vinayak S.,Dharmaraja, Allimuthu T.,Chakrapani, Harinath
supporting information; experimental part, p. 3766 - 3769 (2012/07/27)
Here we report a series of 2-aryl-3-amino-1,4-naphthoquinones that generated reactive oxygen species (ROS) such as superoxide and hydrogen peroxide upon incubation in pH 7.4 under ambient aerobic conditions. ROS generation from these compounds was sensitive to structural modifications at the 3-amino position and a 2-aryl substituent promoted ROS generation. A number of these compounds were found to induce DNA damage in the presence of Cu(II) without any added reducing agent. Our data suggests that 2-aryl-3-amino-1,4-naphthoquinones' propensity to produce ROS correlated well with its DNA damage inducing ability. 2-Phenyl-3-pyrrolid-1-yl-1,4-naphthoquinone (22) was found to damage DNA at 1 μM suggesting that these compounds may have therapeutic relevance in targeting cancers which over-express Cu(II).
A SUCCESSFUL PREPARATION OF 2-ARYL-2,3-DIHYDRO-2,3-IMINO-1,4-NAPHTHOQUINONES
Maruyama, Kazuhiro,Ogawa, Takuji
, p. 1027 - 1028 (2007/10/02)
A new class of compounds, 2-aryl-2,3-dihydro-2,3-imino-1,4-naphthoquinones 3, was synthesized for the first time by heating 2-aryl-1,4-naphthoquinones with aryl azides.The yields were 30-50percent when p-methoxyphenyl azide was used.
