186901-93-9Relevant articles and documents
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase
Penning, Thomas D.,Chandrakumar, Nizal S.,Desai, Bipin N.,Djuric, Stevan W.,Gasiecki, Alan F.,Liang, Chi-Dean,Miyashiro, Julie M.,Russell, Mark A.,Askonas, Leslie J.,Gierse, James K.,Harding, Elizabeth I.,Highkin, Maureen K.,Kachur, James F.,Kim, Suzanne H.,Villani-Price, Doreen,Pyla,Ghoreishi-Haack, Nayereh S.,Smith, Walter G.
, p. 3383 - 3386 (2007/10/03)
The synthesis and biological evaluation of a series of functionalized pyrrolidine- and piperidine-containing analogues of our lead LTA4 hydrolase inhibitor, SC-57461A, is described. A number of compounds showed excellent potency in our in vitro
