186953-20-8

Upstream product

• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 115869-43-7 (tert-butyldiphenylsilanyloxy)acetaldehyde 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 136787-49-0 3-(tert-butyldiphenylsilyloxy)prop-1-ene 

Downstream Products

• 186953-43-5 (7E,9Z,13E)-tert-butyldiphenylsilyl 9,13-didemethyl-9,13-difluororetinyl ether 
• 186953-39-9 (7E,9E,13E)-tert-butyldiphenylsilyl 13-demethyl-13-fluororetinyl ether 
• 186953-27-5 (2E,4E)-tert-butyldiphenylsilyl 3-fluoro-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-yl ether 
• 186953-22-0 (2E)-4-[(tert-butyldiphenylsilyl)oxy]-2-fluorobut-2-enal 
• 186953-21-9 (E)-ethyl 4-(tert-butyldiphenylsilanyloxy)-2-fluoro-2-butenol 

Relevant academic research and scientific papers

Design and synthesis of novel fluorocyclopropanoid nucleosides

Novel fluorocyclopropanoid nucleosides were designed, synthesized and evaluated their antiviral activities against poliovirus, HSV, HIV, and HBV.

Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases

Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

Synthesis of Retinals Fluorinated at Odd-Numbered Side-Chain Positions and of the Corresponding Fluorobacteriorhodopsins

Conventional Horner-Wadsworth-Emmons and Wittig condensations were used to fluorinate the odd-numbered positions of the retinal side chain past C7. The stereochemically labile cis-fluororetinals were easily converted into the most stable trans-fluororetinals, which were incubated with bacterio-opsin. Contrary to expectations, the fluorinated retinals provided artificial pigments with near normal absorption properties, showing that any electrostatic interactions between the fluorine atoms and protein groups were insufficient to prevent normal binding. The new artificial pigments had smaller opsin shifts than did native bacteriorhodopsin, which is interpreted as due either to greater electrostatic interaction between the protonated imine and its counterion, or to local interactions between the fluorine substituents and nearby polar protein groups.