187035-46-7Relevant academic research and scientific papers
Iminium Carbonic Acid Derivative Salts. IX [1]. Synthesis of N,S-Containing Heterobicycles from N-Protected 2-Methylthio-1,3-thiazinium and 2-Methylthiothiazolium Salts Part 1. Preparation of N-Protected 2-Methylthio-1,3-thiazinium and 2-Methylthiothiazolium Salts and their Reaction with CH-Acidic Compounds
Hanefeld, Wolfgang,Naeeni, Mahmoud,Schlitzer, Martin
, p. 1785 - 1790 (1996)
N-Boc-protected 1,3-thiazine-2-thiones and thiazolidin-2-thiones were transformed into the corresponding 2-methylthio-1,3-thiazinium and 2-methylthiothiazolium salts by methyl iodide or trimethyloxonium tetrafluoroborate. This activated species were reacted with CH-acidic compounds forming ketene-N,S-acetals. The protection group was removed with trifluoracetic acid to yield the N-unsubstituted ketene-N,S-acetals.
