18706-21-3

Basic information

• Product Name: 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE;BUTTPARK 147\04-65;6-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline 97%;6-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline97%;6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL;2-TrifluoroMethyl-4-hydroxy-6-chloroquinoline;6-Chloro-2-(trifluoroMethyl) quinoline-4 –ol
• CAS NO: 18706-21-3
• Molecular Formula: C10H5ClF3NO
• Molecular Weight: 247.6
• Mol File: 18706-21-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 280 °C
• Boiling Point: 263.268 °C at 760 mmHg
• Flash Point: 113.021 °C
• Appearance: /
• Density: 1.5 g/m³
• Vapor Pressure: 0.0136mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(18706-21-3)
• EPA Substance Registry System: 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(18706-21-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 18706-21-3(Hazardous Substances Data)

Usage

Description

6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE is a chemical compound characterized by a quinoline backbone with a chloro, hydroxy, and trifluoromethyl substitution. It is known for its potential applications in the pharmaceutical and agrochemical industries due to its unique structural features that contribute to enhanced metabolic stability, bioavailability, and diverse biological activities.

Uses

Used in Pharmaceutical Industry:
6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to improve the metabolic stability and bioavailability of drug candidates. The trifluoromethyl group enhances the lipophilicity and membrane permeability of the resulting drugs, thereby increasing their effectiveness.
6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE is also used as a potential lead compound in drug discovery and development due to the quinoline scaffold's demonstrated antimalarial, antiviral, and anticancer activities. Its versatile chemical structure allows for further modifications to optimize its therapeutic properties and target specific diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE is utilized as a building block for the development of novel agrochemicals with improved efficacy and selectivity. The quinoline core, along with the chloro and trifluoromethyl substituents, can be tailored to create compounds with enhanced pesticidal properties, such as herbicidal, insecticidal, or fungicidal activities.
Overall, 6-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE is a valuable chemical compound with a wide range of applications in both the pharmaceutical and agrochemical sectors, owing to its unique structural features and potential for further chemical modifications to achieve desired biological activities.

InChI:InChI=1/C10H5ClF3NO/c11-6-3-1-2-5-7(16)4-8(10(12,13)14)15-9(5)6/h1-4H,(H,15,16)