18706-25-7 Usage
Description
4-bromo-2-(trifluoromethyl)quinoline is a quinoline derivative with the molecular formula C10H5BrF3N. It is a heterocyclic aromatic organic compound that features a bromine atom and a trifluoromethyl group attached to the quinoline ring. 4-bromo-2-(trifluoromethyl)quinoline is of interest to researchers in medicinal chemistry and drug discovery due to the specific chemical and pharmacological properties imparted by the bromine and trifluoromethyl groups.
Uses
Used in Organic Synthesis:
4-bromo-2-(trifluoromethyl)quinoline is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure allows for the formation of new molecules with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-bromo-2-(trifluoromethyl)quinoline is used as a starting material for the development of new drugs. Its quinoline structure and functional groups can be modified to design molecules with specific biological activities, targeting various therapeutic areas.
Used in Medicinal Chemistry:
4-bromo-2-(trifluoromethyl)quinoline is utilized in medicinal chemistry for the exploration of its potential as a lead compound. Researchers investigate its interactions with biological targets and evaluate its pharmacological properties to assess its suitability for further drug development.
Used in Agrochemical Development:
In the agrochemical industry, 4-bromo-2-(trifluoromethyl)quinoline may have potential applications as a building block for the development of new pesticides or other agrochemicals. Its unique structure and functional groups can be exploited to create molecules with specific modes of action against pests or diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 18706-25-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,0 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18706-25:
(7*1)+(6*8)+(5*7)+(4*0)+(3*6)+(2*2)+(1*5)=117
117 % 10 = 7
So 18706-25-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H5BrF3N/c11-7-5-9(10(12,13)14)15-8-4-2-1-3-6(7)8/h1-5H
18706-25-7Relevant articles and documents
Preparation method of quinolone derivate
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Paragraph 0020; 0021; 0022, (2018/07/30)
The invention discloses a preparation method of a quinolone derivate 1-(2-(trifluoromethyl) quinolone-4-gruop) ethylamine. The method is characterized in that 2-(trifluoromethyl) quinolone-4-alcohol is used as the initial raw material and is subjected to bromination, cyaniding, grignard reaction and amination reduction to obtain a target product. The compound is an important intermediate of a medicine.
Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones
Marull, Marc,Schlosser, Manfred
, p. 1576 - 1588 (2007/10/03)
The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
