1870899-46-9

Basic information

• Product Name: Azadibenzocyclooctyne-PEG4-acid
• Synonyms: Azadibenzocyclooctyne-PEG4-acid;DBCO-NH-PEG4-CH2CH2COOH;DBCO-PEG4-CH2CH2COOH
• CAS NO: 1870899-46-9
• Molecular Formula: C32H40N2O9
• Molecular Weight: 596.67
• Mol File: 1870899-46-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 855.9±65.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Solubility: Soluble in Water, DMSO, DMF, DCM
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: Azadibenzocyclooctyne-PEG4-acid(CAS DataBase Reference)
• NIST Chemistry Reference: Azadibenzocyclooctyne-PEG4-acid(1870899-46-9)
• EPA Substance Registry System: Azadibenzocyclooctyne-PEG4-acid(1870899-46-9)

Safety Data

• Hazardous Substances Data: 1870899-46-9(Hazardous Substances Data)

Usage

Description

Azadibenzocyclooctyne-PEG4-acid, also known as DBCO-NHCO-PEG5-acid, is an analog of DBCO-Acid with a hydrophilic PEG spacer arm. This reagent is a non-activated building block with enhanced solubility in aqueous media, allowing it to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Used in Bioconjugation:
Azadibenzocyclooctyne-PEG4-acid is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The PEG spacer arm improves the solubility and stability of the conjugates, while the DBCO group enables copper-free Click Chemistry reactions for efficient and site-specific conjugation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azadibenzocyclooctyne-PEG4-acid is used as a component in drug delivery systems. The PEG spacer arm enhances the solubility and biocompatibility of drug carriers, while the DBCO group allows for the site-specific attachment of therapeutic agents through Click Chemistry, improving the targeting and efficacy of drug delivery.
Used in Materials Science:
In materials science, Azadibenzocyclooctyne-PEG4-acid is used as a building block for the development of functional materials. The PEG spacer arm provides improved solubility and stability, while the DBCO group enables the formation of complex architectures through copper-free Click Chemistry, allowing for the creation of advanced materials with tailored properties.