18711-13-2

Usage

Chemical Properties

orange flakes

InChI:InChI=1/C8H3Cl2NO2/c9-3-1-2-4(10)6-5(3)7(12)8(13)11-6/h1-2H,(H,11,12,13)

Upstream product

• 17122-58-6 N-(2,5-dichlorophenyl)-2-(hydroxyimino)acetamide 
• 95-82-9 2,5 dichloroaniline 

Downstream Products

• 1292780-42-7 C₁₇H₁₀Cl₂N₄O₃S 
• 1201799-32-7 2-fluorobenzaldehyde-N-(4,7-dichloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone 
• 1201799-36-1 2-hydroxy,3-methoxybenzaldehyde-N-(4,7-dichloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone 
• 1201799-37-2 3,4-dimethoxybenzaldehyde-N-(4,7-dichloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazone 
• 1160247-83-5 C₁₆H₁₁Cl₂NO₃ 
• 1160248-75-8 C₁₆H₁₁Cl₂NO₂ 
• 1155338-37-6 1-(4',7'-dichloroisatin)-4-(4'-methoxyphenyl)-3-thiosemicarbazone 
• 667914-33-2 YK-4-275 
• 74409-79-3 2-Amino-3,6-dichlorothiobenzamide 
• 108053-96-9 4,4',7,7'-tetrachloro-2,2'-(propane-1,3-diyldiimino)bis(benzoic acid) 
• 108053-97-0 4,4',7,7'-tetrachloro-2,2'-(propane-1,3-diyldiimino)bis(benzyl alcohol) 
• 108053-98-1 4,4',7,7'-tetrachloro-2,2'-(propane-1,3-diyldiimino)bis(benzaldehyde) 

Relevant academic research and scientific papers

Reductive ring closure methodology toward heteroacenes bearing a dihydropyrrolo[3,2- B ]pyrrole core: Scope and limitation

A newly developed reductive ring closure methodology to heteroacenes bearing a dihydropyrrolo[3,2-b]pyrrole core was systematically studied for its scope and limitation. The methodology involves (i) the cyclization of an o-aminobenzoic acid ester derivative to give an eight-membered cyclic dilactam, and (ii) the conversion of the dilactams into the corresponding diimidoyl chloride, which undergoes (iii) reductive ring closure to install the dihydropyrrolo[3,2-b]pyrrole core. The first step of the methodology plays the key role due to its substrate limitation, which suffers from the competition of oligomerization and hydrolysis. All the dilactams could successfully convert to the corresponding diimidoyl chlorides, most of which succeeded to give the dihydropyrrolo[3,2-b]pyrrole core. The influence of the substituents and the elongation of conjugated length on the photophysical properties of the obtained heteroacenes were then investigated systematically using UV-vis spectroscopy and cyclic voltammetry. It was found that chlorination and fluorination had quite a different effect on the photophysical properties of the heteroacene, and the ring fusing pattern also had a drastic influence on the band gap of the heteroacene. The successful preparation of a series of heteroacenes bearing a dihydropyrrolo[3,2-b]pyrrole core would provide a wide variety of candidates for further fabrication of organic field-effect transistor devices.

Synthesis of substituted picenes through Pd-catalyzed cross-coupling reaction/annulation sequences and their physicochemical properties

A novel and versatile synthetic method for picene derivatives is developed using the Pd-catalyzed intramolecular double cyclization of the corresponding 2,3-bis[(1Z)-2-phenylethenyl]-1,4-dichlorobenzenes, which are readily prepared by Suzuki-Miyaura cross-coupling reactions of polyhalobenzenes with (Z)-arylethenylboronates. The physical properties of the obtained picenes can be modified via introducing a variety of functional groups to the picene framework. All compounds are investigated by UV-vis and fluorescence spectroscopic measurements, CV, and DFT calculations as well as X-ray diffraction analysis.

ORGANIC COMPOUNDS

The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

PTEN INHIBITORS

The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.