187110-83-4Relevant articles and documents
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump
Leonessa, Fabio,Kim, Ji-Hyun,Ghiorghis, Alem,Kulawiec, Robert J.,Hammer, Charles,Talebian, Abdelhossein,Clarke, Robert
, p. 390 - 398 (2002)
The P-glycoprotein product (Pgp) of the MDR1 gene has been implicated in the multiple drug resistance phenotype expressed by many cancers. Functioning as an efflux pump, P-glycoprotein prevents the accumulation of high intracellular concentrations of subs