18720-35-9

Basic information

• Product Name: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
• Synonyms: Bicyclo[2.2.2]octane-1,4-dicarboxylIic acid hemimethyl ester;Bicyclo [2.2.2]octane-1,4-dicarboxylic acid, 1-methyl ester;Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, monomethyl ester;4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-;1-Carboxy-4-(Methoxycarbonyl)bicyclo[2.2.2]octane;4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid, >=98%;4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid;BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
• CAS NO: 18720-35-9
• Molecular Formula: C₁₁H₁₆O₄
• Molecular Weight: 212.24
• EINECS: 1308068-626-2
• Product Categories: Carboxylic Acids;Carboxylic Acids;Fused Ring Systems
• Mol File: 18720-35-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 186.0 to 190.0 °C
• Boiling Point: 322.473 °C at 760 mmHg
• Flash Point: 122.436 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 4.77±0.10(Predicted)
• CAS DataBase Reference: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(18720-35-9)
• EPA Substance Registry System: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(18720-35-9)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 18720-35-9(Hazardous Substances Data)

Usage

Uses

4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic Acid has been used as a reactant for the preparation of bicyclo-octyltriazole inhibitors of HSD1 for metabolic syndrome treatment.

InChI:InChI=1/C11H16O4/c1-15-9(14)11-5-2-10(3-6-11,4-7-11)8(12)13/h2-7H2,1H3,(H,12,13)

Upstream product

• 1459-96-7 dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 
• 106004-06-2 dimethyl 1-(2'-chloroethyl)cyclohexane-1,4-dicarboxylate 
• 619-81-8 cyclohexane-1,4-dicarboxylic acid 
• 1659-96-7 1,4-dibromo-trans-cyclohexane-1,4-dicarboxylic acid dimethyl ester 
• 100-21-0 terephthalic acid 
• 1659-67-2 dimethyl bicyclo[2.2.2]oct-2-ene-1,4-dicarboxylate 
• 1659-95-6 dimethyl 1,3-cyclohexadiene-1,4-dicarboxylate 
• 953-69-5 4-phenylbicyclo<2.2.2>octane-1-carboxylic acid 
• 174685-35-9 dimethyl 1'H,4'H-dispiro[1,3-dithiolane-2,2'-bicyclo[2.2.2]octane-5',2''-[1,3]dithiolane]-1',4'-dicarboxylate 
• 6289-46-9 dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate 
• 57293-62-6 dimethyl 1,4-dioxobicyclo<2.2.2>octane-2,5-dicarboxylate 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 23062-52-4 methyl 4-phenylbicyclo<2.2.2>octane-1-carboxylate 

Downstream Products

• 862501-91-5 methyl 4-(((benzyloxy)carbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate 
• 23062-52-4 methyl 4-phenylbicyclo<2.2.2>octane-1-carboxylate 
• 23042-19-5 methyl 4-(4-nitrophenyl)bicyclo[2.2.2]octane-1-carboxylate 
• 1127-13-5 4-hydroxybicyclo[2.2.2]octane-1-carboxylic acid 
• 23062-53-5 methyl 4-hydroxybicyclo<2.2.2>octane-1-carboxylate 
• 94994-25-9 4-carbomethoxybicyclo<2.2.2>octane-1-carboxaldehyde 
• 959958-69-1 3-(4-(6-amino-2,4-dioxo-1-propyl-3-heptadeuteriopropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-bicyclo[2.2.2]oct-1-yl)propionic acid methyl ester 
• 96102-85-1 4-formyl-bicyclo[2.2.2]octane-1-carboxylic acid 
• 135908-45-1 ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate 
• 13595-17-0 4-amino-bicyclo[2.2.2]octane-1-carboxylic acid 
• 1245643-16-6 4-(difluoromethyl)bicyclo[2.2.2]octan-1-amine 

Relevant articles and documents

Bicyclo [2.2.2] octane - 1, 4 - dicarboxylic acid mono methyl ester synthesis method

The invention relates to a synthetic method of an organic compound. The synthetic method of bicyclo-[2.2.2]octane-1,4-dicarboxylic acid monomethyl easter is as follows: firstly, adopting sodium hydride, DMSS and 1,2-dibromoethane to synthesize the intermediate I; secondly, adopting the intermediate I, sodium acetate, ammourea hydrochloride and alcohol to synthesize semicarbazon; thirdly, adopting potassium hydroxide, diethylene glycol and semicarbazon to synthesize target diacid; fourthly, adopting target diacid, thionyl chloride and methanol to synthesize target diester; and fifthly, adopting target diester, potassium hydroxide and 95% of methanol water solution to synthesize the target product monoester. The invention has reasonable synthetic process route, mild process conditions, environment friendly, easy operation, low raw material cost, high product yield and excellent purity, and is applicable to industrial production and satisfies the application requirement of each industry.

Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors

The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

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