187218-03-7

Basic information

• Product Name: (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE
• Synonyms: (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HCL;(R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE;H-D-TQA-OH HCL;H-D-TIC-(C*CH2)OH HCL;(R)-2-tetrahydroisoquinolineaceticacidCl;(R)-1,2,3,4-Tetrahydro-3-isoquinolineacetic acid hydrochloride;(R)-2-Tetrahydroisoquinoline acetic acid
• CAS NO: 187218-03-7
• Molecular Formula: C11H14ClNO2
• Molecular Weight: 227.69
• Product Categories: 3-Amino-4-phenylbutanoic Acid Analogs;B-Amino
• Mol File: 187218-03-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 412.4 °C at 760 mmHg
• Flash Point: 203.2 °C
• Appearance: /
• Vapor Pressure: 1.54E-07mmHg at 25°C
• CAS DataBase Reference: (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE(187218-03-7)
• EPA Substance Registry System: (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE(187218-03-7)

Safety Data

• Hazardous Substances Data: 187218-03-7(Hazardous Substances Data)

Usage

General Description

(R)-2-Tetrahydroisoquinoline acetic acid hydrochloride is a chemical compound with the formula C11H14NO2Cl. It is a derivative of tetrahydroisoquinoline, a heterocyclic compound containing a 6-membered ring with one nitrogen atom. (R)-2-TETRAHYDROISOQUINOLINE ACETIC ACID HYDROCHLORIDE is in the form of a white solid, and it is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. It has also been studied for its potential neuroprotective and anti-inflammatory properties, making it a promising candidate for the development of new therapeutic agents. Additionally, (R)-2-Tetrahydroisoquinoline acetic acid hydrochloride has potential applications in the treatment of neurological and psychiatric disorders due to its ability to modulate neurotransmitter systems in the brain.

InChI:InChI=1/C11H13NO2.ClH/c13-11(14)6-10-5-8-3-1-2-4-9(8)7-12-10;/h1-4,10,12H,5-7H2,(H,13,14);1H/t10-;/m1./s1

Upstream product

• 50-00-0 formaldehyd 
• 138165-77-2 (S)-3-amino-4-phenylbutanoic acid hydrochloride 

Relevant articles and documents

1-BENZYLSPIRO[PIPERIDINE-4,1′-PYRIDO[3,4-b]indole] ‘co-potentiators’ for minimal function CFTR mutants

We previously identified a spiro [piperidine-4,1-pyrido [3,4-b]indole] class of co-potentiators that function in synergy with existing CFTR potentiators such as VX-770 or GLGP1837 to restore channel activity of a defined subset of minimal function cystic fibrosis transmembrane conductance regulator (CFTR) mutants. Here, structure-activity studies were conducted to improve their potency over the previously identified compound, 20 (originally termed CP-A01). Targeted synthesis of 37 spiro [piperidine-4,1-pyrido [3,4-b]indoles] was generally accomplished using versatile two or three step reaction protocols with each step having high efficiency. Structure-activity relationship studies established that analog 2i, with 6′-methoxyindole and 2,4,5-trifluorobenzyl substituents, had the greatest potency for activation of N1303K-CFTR, with EC50 ～600 nM representing an ～17-fold improvement over the original compound identified in a small molecule screen.