187221-31-4

Basic information

• Product Name: Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-
• Synonyms: 1-(1,2,3,4-Tetrahydro-phthalen-1-yl)-piperazine;1-(1,2,3,4-tetrahydro-1-naphthalenyl)piperazine;1-(1,2,3,4-Tetrahydronaphthalen-1-yl)piperazine;Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-
• CAS NO: 187221-31-4
• Molecular Formula: C₁₄H₂₀N₂
• Molecular Weight: 216.32
• Mol File: 187221-31-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-(187221-31-4)
• EPA Substance Registry System: Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-(187221-31-4)

Safety Data

• Hazardous Substances Data: 187221-31-4(Hazardous Substances Data)

Usage

General Description

Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)- is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It is classified as a piperazine derivative, which is a type of organic compound containing a six-membered heterocyclic ring with two nitrogen atoms at opposite positions. This specific compound contains a tetrahydro-1-naphthalenyl group, which is a fused polycyclic hydrocarbon structure, consisting of a naphthalene ring with an additional saturated cyclohexane ring. The presence of these structural elements gives the compound potential biological activity and makes it useful in drug development and chemical research. However, it is important to handle this chemical with care due to its potential hazards and toxic effects.

Upstream product

• 159671-85-9 ethyl 4-(1,2,3,4-tetrahydronaphth-1-yl)piperazine-1-carboxylate 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 229345-38-4 tert-butyl 4-(1,2,3,4-tetrahydronaphthalen-1-yl)piperazine-1-carboxylate 
• 58485-68-0 1-chlorotetralin 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 

Relevant articles and documents

NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Synthesis by microwave irradiation and binding properties of novel 5-HT1A receptor ligands

This work reports the synthesis by microwave irradiation and the binding tests on the 5-HT1A, 5-HT2A and 5-HT2C receptors of new substituted piperazines in order to identify selective ligands for 5-HT1A subtype receptor. Conventional heating and microwave irradiation of the reactions was compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. Some resulting active compounds (29 and 39) were characterised by a good selectivity profile for the 5-HT1A subtype receptor. The more active compounds were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1, α2 adrenergic receptors. The compound with higher affinity and selectivity for the 5-HT1A over all the considered receptors was the 3-{4-[4-(1,2,3,4-tetrahydronaphthyl)-1-piperazinyl]butan}-benzotriazinone (-)29 (5-HT1A Ki=36 nM, other receptors not active).

Synthesis of 1-[ω-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)piperazines

A series of 1-[co-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)-piperazines (1a-v) was prepared either by reacting the precursor 4-[ω-[(arylamino)carbonyl]alkyl]piperazine (2a-j) with 1-chlorobenzocycloalkanes (3a-c) (Procedure A) or by reacting the N-aryl-ω-chloroalkanamides (5a-j) with the 4-(benzocycloalkyl)piperazines (10a-c) (Procedure B). The best yields were obtained using procedure A.