187221-31-4

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activity. Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-'s unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical industry, Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its structural properties make it suitable for creating compounds that can effectively control pests and weeds, thereby enhancing crop protection and yield.
Used in Chemical Research:
Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)is also employed in chemical research as a model compound for studying the properties and reactions of piperazine derivatives. Researchers use Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)- to explore its reactivity, stability, and potential applications in various chemical processes and reactions.
It is crucial to handle Piperazine, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)with care due to its potential hazards and toxic effects. Proper safety measures and precautions should be taken during its synthesis, storage, and use to minimize risks to human health and the environment.

Upstream product

• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 229345-38-4 tert-butyl 4-(1,2,3,4-tetrahydronaphthalen-1-yl)piperazine-1-carboxylate 
• 58485-68-0 1-chlorotetralin 
• 159671-85-9 ethyl 4-(1,2,3,4-tetrahydronaphth-1-yl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Tetrahydrobenzindole derivatives

Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.

Synthesis by microwave irradiation and binding properties of novel 5-HT1A receptor ligands

This work reports the synthesis by microwave irradiation and the binding tests on the 5-HT1A, 5-HT2A and 5-HT2C receptors of new substituted piperazines in order to identify selective ligands for 5-HT1A subtype receptor. Conventional heating and microwave irradiation of the reactions was compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. Some resulting active compounds (29 and 39) were characterised by a good selectivity profile for the 5-HT1A subtype receptor. The more active compounds were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1, α2 adrenergic receptors. The compound with higher affinity and selectivity for the 5-HT1A over all the considered receptors was the 3-{4-[4-(1,2,3,4-tetrahydronaphthyl)-1-piperazinyl]butan}-benzotriazinone (-)29 (5-HT1A Ki=36 nM, other receptors not active).

New benzocycloalkylpiperazines, potent and selective 5-HT(1A) receptor ligands

A series of 1-(benzocycloalkyl)-4-(benzamidoalkyl)piperazine derivatives was prepared in order to obtain compounds with a high affinity and selectivity for 5-HT(1A) receptors. The modifications of aromatic substituents, the length of the alkyl chain, and the size of the ring were explored. Most of N-(1,2,3,4-tetrahydronaphthyl)-N'- (benzamidoethyl)piperazines (32-37) were bound to 5-HT(1A) receptors in a nanomolar range and presented a high degree of selectivity. After resolution, levorotatory enantiomers showed affinity and selectivity higher than those of dextrorotatory ones for 5-HT(1A) sites. The agonist type activity of selected derivatives was also confirmed in vitro on the inhibition of the activation of adenylate cyclase induced by forskolin and, in vivo, on the induction of the lower lip retraction in rats.

Synthesis of 1-[ω-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)piperazines

A series of 1-[co-[(arylamino)carbonyl]alkyl]-4-(benzocycloalkyl)-piperazines (1a-v) was prepared either by reacting the precursor 4-[ω-[(arylamino)carbonyl]alkyl]piperazine (2a-j) with 1-chlorobenzocycloalkanes (3a-c) (Procedure A) or by reacting the N-aryl-ω-chloroalkanamides (5a-j) with the 4-(benzocycloalkyl)piperazines (10a-c) (Procedure B). The best yields were obtained using procedure A.