187227-32-3Relevant academic research and scientific papers
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
Kim, Choung U.,Lew, Willard,Williams, Matthew A.,Liu, Hongtao,Zhang, Lijun,Swaminathan,Bischofberger, Norbert,Chen, Ming S.,Mendel, Dirk B.,Tai, Chun Y.,Laver, W. Graeme,Stevens, Raymond C.
, p. 681 - 690 (2007/10/03)
The design, synthesis, and in vitro evaluation of the novel carbocycles as transition-state-based inhibitors of influenza neuraminidase (NA) are described. The double bond position in the carbocyclic analogues plays an important role in NA inhibition as d
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Williams, Matthew A.,Lew, Willard,Mendel, Dirk B.,Tai, Chun Y.,Escarpe, Paul A.,Laver, W. Graeme,Stevens, Raymond C.,Kim, Choung U.
, p. 1837 - 1842 (2007/10/03)
The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influenza A and B viruses.
