187277-07-2

Basic information

• Product Name: 1-p-Tolyl-1H-imidazole-4,5-dicarboxylic acid di-tert-butyl ester
• Synonyms: 1-p-Tolyl-1H-imidazole-4,5-dicarboxylic acid di-tert-butyl ester
• CAS NO: 187277-07-2
• Molecular Weight: 358.437
• Mol File: 187277-07-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-p-Tolyl-1H-imidazole-4,5-dicarboxylic acid di-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-p-Tolyl-1H-imidazole-4,5-dicarboxylic acid di-tert-butyl ester(187277-07-2)
• EPA Substance Registry System: 1-p-Tolyl-1H-imidazole-4,5-dicarboxylic acid di-tert-butyl ester(187277-07-2)

Safety Data

• Hazardous Substances Data: 187277-07-2(Hazardous Substances Data)

Upstream product

• 33604-67-0 (4-methylphenyl)azo 4-methylphenyl sulfone 
• 2769-72-4 tert-Butyl isocyanoacetate 

Relevant articles and documents

Reactions of arylazosulfones with the conjugate bases of (tert-butoxycarbonyl)methyl and tosylmethyl isocyanide. Synthesis of substituted 1-arylimidazoles

The reactions of arylazosulfones 1 (ArN = NSO2Ar') with the potassium salts of (tert-butoxycarbonyl)methyl 2 and tosylmethyl isocyanide 3 in DMSO afford 4,5-bis(tert-butoxycarbonyl)- 4 and 4-tosyl-1-arylimidazoles 5, respectively. Yields of imidazoles 4 and 5 vary from moderate to excellent depending on the nature both of Ar in 1 and of the nucleophile (2 or 3) employed. A comparison of the results obtained with those relevant to the reactions of the same nucleophiles with nitrosobenzene in analogous experimental conditions provides useful mechanistic indications on the transformation of 1 to 4 or 5.