187333-96-6

Basic information

• Product Name: [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester
• Synonyms: [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester;[(1R,2S)-2-Hydroxycyclohexyl]carbamic Acid Phenylme thyl Ester,99%e.e.
• CAS NO: 187333-96-6
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.30556
• Mol File: 187333-96-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(187333-96-6)
• EPA Substance Registry System: [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester(187333-96-6)

Safety Data

• Hazardous Substances Data: 187333-96-6(Hazardous Substances Data)

Usage

General Description

The chemical compound, [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester, is a derivative of carbamic acid with a phenylmethyl ester group attached. It is derived from a cyclohexyl carbanion intermediate, resulting in a cyclohexyl carbamic acid derivative. [(1R,2S)-2-hydroxycyclohexyl]CarbaMic acidphenylMethyl ester may have applications in pharmaceuticals, particularly as a potential drug candidate for the treatment of various medical conditions. The specific properties and potential uses of this compound would require further investigation and testing.

Upstream product

• 501-53-1 benzyl chloroformate 
• 291533-28-3 (1S,2R)-2-(tert-butoxycarbonylamino)cyclohexan-1-ol 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 189942-50-5 (3aR,7aS)-hexahydrobenzo[d]oxazol-2(3H)-one 
• 291533-10-3 2-(tert-butoxycarbonylamino)cyclohexanone 
• 108267-20-5 cis-2-amino-cyclohexanol 
• 92645-06-2 (+/-)-cis-benzyl N-(2-hydroxycyclohexyl)carbamate 
• 91174-01-5 sodium [(benzyloxy)carbonyl]chloroamide 
• 110-83-8 cyclohexene 
• 38898-70-3 cis-2-amino-cyclohexanol-⁽¹⁾ 

Downstream Products

• 837377-38-5 (1S,2R)-2-amino-cyclohexan-1-ol formate 

Relevant articles and documents

NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS

This invention relates to nicotinamide derivatives of formula (I) and to pharmaceutical compositions containing, and the uses of such derivatives as PDE4 inhibitors wherein R7 is attached to the 3-or 4-position of the phenyl ring and is S(O)pR8, R8 is (C1-C4)alkyl optionally substituted by (C3-C6)cycloalkyl; m is 0 or 1; L is a (C3-C8)carbocyclic non-aromatic ring; and the remaining variables are as defined in the claims.

Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: Access to enantiopure cyclic cis-amino alcohols

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10-21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.

Enzymatic resolution of (±)-cis-2-aminocyclopentanol and (±)-cis-2- aminocyclohexanol

(±)-cis-N-Benzyloxycarbonyl-2-aminocyclopentanol was efficiently resolved by O-acylation with Pseudomonas cepacia lipase, as was (±)-cis-N- benzyloxycarbonyl-2-aminocyclohexanol when Candida antarctica lipase was used.