187344-68-9 Usage
General Description
(6-Bromo-8-(methylamino)imidazo[1,2-a]pyrazin-3-yl)methanol is a chemical compound with a molecular formula C9H10BrN5O. It is a white to off-white solid that is mainly used as a reagent or intermediate in the synthesis of various pharmaceutical compounds. It is also used in the research and development of new drugs due to its potential pharmacological properties. The compound contains a bromine atom, a methylamino group, and a hydroxyl group, and it belongs to the class of imidazo[1,2-a]pyrazine derivatives. Due to its structural features, it may exhibit biological activity and is of interest in medicinal chemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 187344-68-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,3,4 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 187344-68:
(8*1)+(7*8)+(6*7)+(5*3)+(4*4)+(3*4)+(2*6)+(1*8)=169
169 % 10 = 9
So 187344-68-9 is a valid CAS Registry Number.
187344-68-9Relevant articles and documents
Synthesis and Antibronchospastic Activity of 8-Alkoxy- and 8-(Alkylamino)imidazopyrazines
Bonnet, Pierre A.,Michel, Alain,Laurent, Florence,Sablayrolles, Claire,Rechencq, Eliane,et al.
, p. 3353 - 3358 (2007/10/02)
Theophylline still occupies a dominant place in asthma therapy.Unfortunatly its adverse central nervous system (CNS) stimulant effects can dramatically limit its use, and adjustments in the dosage are often needed.We have synthesized a new series of imidazopyrazine derivatives which are much more potent bronchodilators than theophylline in vivo and do not exhibit the CNS stimulatory profile.In vitro studies on isolated rat uterus and guinea pig trachea confirm the high potentialities of these derivatives. 6-Bromo-8-(methylamino)imidazopyrazine-3-carbonitrile (23) is identified as the most potent compound of the series.As i n the case of theophylline, phosphodiesterase inhibition appears unlikely to be the unique mechanism of the action of this series of heterocycles.