187389-53-3 Usage
Uses
Different sources of media describe the Uses of 187389-53-3 differently. You can refer to the following data:
1. N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.
2. Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
Check Digit Verification of cas no
The CAS Registry Mumber 187389-53-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,3,8 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 187389-53:
(8*1)+(7*8)+(6*7)+(5*3)+(4*8)+(3*9)+(2*5)+(1*3)=193
193 % 10 = 3
So 187389-53-3 is a valid CAS Registry Number.
187389-53-3Relevant articles and documents
Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity
Witte, Martin D.,Descals, Carlos V.,De Lavoir, Sebastiaan V. P.,Florea, Bogdan I.,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.
, p. 3690 - 3697 (2008/10/09)
In this paper the development of a fluorescent activity based probe, Bodipy-VAD-Fmk, for visualization of yeast peptide N-glycanase is described. The activity based probe is used to assess the efficacy of known and new chitobiose-based electrophilic traps to bind yeast peptide N-glycanase. The Royal Society of Chemistry.
