187393-12-0Relevant articles and documents
INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS
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Page 7, (2008/06/13)
The present invention provides compounds of formula (1) wherein R1 and R2 each independently represent hydrogen, hydroxy, F, Cl, Br, I, CN, 1 to 6 carbon alkyl, 1 to 6 carbon alkoxy, nitro CF3 and phenyloxy or benzyloxy, in which the aromatic ring can be optionally substituted by from 1 to 3 groups selected from C1-C6 alkoxy (preferably OMe), F, Cl, Br, I, and CF3; R3 and R4 are each independently a hydrogen, a 1 to 6 carbon alkyl or a CH2Ph in which the phenyl ring can be optionally substituted by from 1 to 3 groups selected from C1-C6 alkoxy (preferably OMe), F, Cl, Br, I, and CF3; Y is selected from CH2 or CH and, X is selected from a group represented by N, CR3, CHR3, CHCH; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of using the compounds to treat central nervous system disorders, such as depression, anxiety, drug withdrawal, eating and sexual disorders and other conditions for which serotonin reuptake inhibitors are used.
Synthesis and Properties of N-2,3-Epoxypropyl Imidazole and Bisimidazole Derivatives
Korotkikh,Shvaika
, p. 1037 - 1046 (2007/10/03)
A number of mono- and bis-(2,3-epoxypropyl) derivatives of imidazoles, benzimidazoles, and bisbenzimidazoles, as well as their salts, were synthesized starting from corresponding azoles and 1-chloro-2,3-epoxypropane. On the basis of 1H NMR and IR spectral data, one of the y-protons in the oxirane ring is presumed to participate in intramolecular H-π interaction with aromatic rings of the azoles. The obtained compounds exhibit antitumor activity and luminescent properties and are potential hardeners and cohardeners for epoxy resins.
