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187526-95-0

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187526-95-0 Usage

Description

(S)-2-(2-aMino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) is a hydrochloride salt derivative of the isoindoline-1,3-dione class, characterized by a chiral center and an amino-phenyl side chain. (S)-2-(2-aMino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) holds promise for pharmaceutical applications and may possess various biological activities, although further research is necessary to ascertain its precise properties and potential uses.

Uses

Used in Pharmaceutical Industry:
(S)-2-(2-aMino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) is used as a potential pharmaceutical compound for its possible biological activities and therapeutic applications. (S)-2-(2-aMino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride)'s unique structure, including the chiral center and amino-phenyl side chain, suggests that it may interact with biological targets in ways that could be beneficial for the treatment of certain conditions.
Used in Research and Development:
In the field of research and development, (S)-2-(2-aMino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) serves as a valuable compound for studying its interactions with various biological systems. This can lead to a better understanding of its potential applications and help in the development of new drugs or therapies based on its structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 187526-95-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,5,2 and 6 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 187526-95:
(8*1)+(7*8)+(6*7)+(5*5)+(4*2)+(3*6)+(2*9)+(1*5)=180
180 % 10 = 0
So 187526-95-0 is a valid CAS Registry Number.

187526-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(2S)-2-Amino-3-phenylpropyl]-1H-isoindole-1,3(2H)-dione hydroc hloride (1:1)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:187526-95-0 SDS

187526-95-0Downstream Products

187526-95-0Relevant articles and documents

PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

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Paragraph 0190; 0191, (2018/05/16)

[Problem] The present invention is to provide a novel pyrazole derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. [Solution] The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, which has TRPM8 inhibitory effects: wherein ring A is C6-10 aryl or the like; X is CR4a or the like; R1 and R2 are a hydrogen atom or the like; R3 is a hydrogen atom or the like; R4 is a hydrogen atom or the like; ring B is C6-10 aryl or the like; R5 is a hydrogen atom or the like; R6a is a hydrogen atom or the like; R7a is a hydrogen atom or the like; R7b is a hydrogen atom or the like; R6b is a hydrogen atom or the like; R8 is a hydrogen atom or the like; n is 0, 1 or 2. Therefore, the compound represented by the formula (I) of the present invention or a pharmaceutically acceptable salt thereof is useful as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons.

Discovery and development of an efficient, scalable, and robust route to the novel CENP-E inhibitor GSK923295A

Bellingham, Richard,Buswell, A. Mark,Choudary, Bernie M.,Gordon, Andrew H.,Moore, Steve O.,Peterson, Matthew,Sasse, Mike,Shamji, Amin,Urquhart, Michael W. J.

experimental part, p. 1254 - 1263 (2011/04/24)

The discovery and development of an efficient manufacturing route to the CENP-E inhibitor 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)- 1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl} -4-[(1-methylethyl)oxy]benzamide (GSK923295A) is described. The existing route to GSK923295A was expensive, nonrobust, used nonideal reagents, and consistently struggled to deliver the API needed for clinical studies. The new synthesis commences from the readily available l-phenylalaninol, which is smoothly converted through to GSK923295A using key Friedel-Crafts acylation as well as selective acylation chemistries. Downstream chemistry to GSK923295A is both high yielding and robust, and the resulting process has been demonstrated first on the kilo scale and subsequently in the pilot plant where 55 kg was successfully prepared. The resulting process is simple, uses cheaper raw materials, is greener in that it avoids using aluminum, tin, and bromination chemistries, and obviates the need for chromatographic purification. Also discussed are the route derived impurities, how they were unambiguously prepared to confirm structure and processing amendments to control their formation, and enhancements to the new process to facilitate future processing.

Solid phase syntheses of oligoureas

Burgess, Kevin,Ibarzo, Javier,Linthicum, D. Scott,Russell, David H.,Shin, Hunwoo,Shitangkoon, Aroonsiri,Totani, Reiko,Zhang, Alex J.

, p. 1556 - 1564 (2007/10/03)

Isocyanates 7 were formed from monoprotected diamines 3 or 6, which in turn can be easily prepared from commercially available N-BOC- or N-FMOC-protected amino acid derivatives. Isocyanates 7, formed in situ, could be coupled directly to a solid support f

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