187527-01-1Relevant academic research and scientific papers
NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS
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Paragraph 0329, (2014/01/09)
Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
Novel high affinity quinoline-based kinase ligands
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Page/Page column 113, (2008/06/13)
Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
Solid-phase and solution-phase syntheses of oligomeric guanidines bearing peptide side chains
Zhang, Zhongsheng,Fan, Erkang
, p. 8801 - 8810 (2007/10/03)
Synthetic strategies for preparing N,N′-bridged oligomeric guanidines bearing peptide side chains both on solid support and in solution are presented. Monomers are prepared from common α-amino acids and therefore contain conventionally protected peptide s
Solid phase syntheses of oligoureas
Burgess, Kevin,Ibarzo, Javier,Linthicum, D. Scott,Russell, David H.,Shin, Hunwoo,Shitangkoon, Aroonsiri,Totani, Reiko,Zhang, Alex J.
, p. 1556 - 1564 (2007/10/03)
Isocyanates 7 were formed from monoprotected diamines 3 or 6, which in turn can be easily prepared from commercially available N-BOC- or N-FMOC-protected amino acid derivatives. Isocyanates 7, formed in situ, could be coupled directly to a solid support f
