187532-77-0

Basic information

• Product Name: C₁₅H₁₂F₂O₂
• CAS NO: 187532-77-0
• Molecular Weight: 262.256
• Mol File: 187532-77-0.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₂F₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₂F₂O₂(187532-77-0)
• EPA Substance Registry System: C₁₅H₁₂F₂O₂(187532-77-0)

Safety Data

• Hazardous Substances Data: 187532-77-0(Hazardous Substances Data)

Upstream product

• 220141-71-9 1‐(chloromethyl)‐3,5‐difluorobenzene 
• 99-93-4 4-Hydroxyacetophenone 

Relevant articles and documents

Natural Products as Sources of New Fungicides (I): Synthesis and Antifungal Activity of Acetophenone Derivatives Against Phytopathogenic Fungi

Several series of 45 acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by 1H and 13C NMR spectroscopy, HRMS and single-crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them, 12 derivatives (e.g., 3a-c, 4c and 4e) exhibited more potent antifungal effects on some phytopathogens than a commercial fungicide hymexazol as positive control. In particular, compound 3b with IC50 values of 10-19μg/mL was found to be the most active in this series and might be a potential lead structure for further optimization. The preliminary structure-activity relationship (SAR) studies of a series of acetophenones are also discussed. A series of acetophenone derivatives have been synthesized and tested for their antifungal activities. Of them 12 derivatives exhibited more potent antifungal effects on some phytopathogens than a positive control hymexazol. Especially, compound 3b (IC50=10-19μg/mL) was found to be the most active and might be a potential lead structure. The SAR of these acetophenones is also discussed.