187616-70-2Relevant academic research and scientific papers
Triazole antifungal agents
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, (2008/06/13)
PCT No. PCT/EP96/02470 Sec. 371 Date Dec. 19, 1997 Sec. 102(e) Date Dec. 19, 1997 PCT Filed Jun. 5, 1996 PCT Pub. No. WO97/01552 PCT Pub. Date Jan. 16, 1997The invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Ar, Z and Het are as defined herein. The compounds of formula (I) possess activity as antifungal agents. The invention also relates to pharmaceutical compositions containing said compounds of formula (I) and to methods of treating fungal infections by administering said compounds of formula (I).
Triazole antifungal agents
-
, (2008/06/13)
An antifungal compound of formula (I): STR1 or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R1 is phenyl substituted with 1 to 3 substituents each independently selected from halo and CF3 ; R2 is (hydroxy)C1 -C4 alkyl, CONH2, S(O)m (C1 -C4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF3 ; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C1 -C4 alkyl or (C1 -C4 alkoxy)methyl.
