1876473-42-5

Basic information

• Product Name: 6,7-dihydro-5H-pyrrolo[1,2-a]iMidazol-3-ylboronic acid
• Synonyms: 6,7-dihydro-5H-pyrrolo[1,2-a]iMidazol-3-ylboronic acid
• CAS NO: 1876473-42-5
• Molecular Formula: C6H9BN2O2
• Molecular Weight: 151.95886
• Mol File: 1876473-42-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 454.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 4.68±0.20(Predicted)
• CAS DataBase Reference: 6,7-dihydro-5H-pyrrolo[1,2-a]iMidazol-3-ylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dihydro-5H-pyrrolo[1,2-a]iMidazol-3-ylboronic acid(1876473-42-5)
• EPA Substance Registry System: 6,7-dihydro-5H-pyrrolo[1,2-a]iMidazol-3-ylboronic acid(1876473-42-5)

Safety Data

• Hazardous Substances Data: 1876473-42-5(Hazardous Substances Data)

Upstream product

• 5419-55-6 Triisopropyl borate 
• 59646-16-1 6,7-dihydro-[5H]pyrrolo[1,2-a]imidazole 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR

The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.