18765-53-2Relevant academic research and scientific papers
Chiral trialkoxysilanols derived from terpene alcohols. Molecular structures of tris([(1S)-endo]-(-)-bornoxy)silanol and tetrakis((-)-menthoxy)silane
Beckmann, Jens,Dakternieks, Dainis,Tiekink, Edward R.T
, p. 188 - 192 (2002)
Terpene alcohols (-)-menthol and [(1S)-endo]-(-)-borneol react with SiCl4 in the presence of base to give (MenO)3SiCl (1) and (BorO)3SiCl (2) in high yields. Hydrolysis of 1 yields (MenO)3SiOH (4) and (MenO)sub
Silicate esters of paclitaxel and docetaxel: Synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potential
Wohl, Adam R.,Michel, Andrew R.,Kalscheuer, Stephen,Macosko, Christopher W.,Panyam, Jayanth,Hoye, Thomas R.
, p. 2368 - 2379 (2014/04/17)
We report here the synthesis and selected properties of various silicate ester derivatives (tetraalkoxysilanes) of the taxanes paclitaxel (PTX) and docetaxel (DTX) [i.e., PTX-OSi(OR)3 and DTX-OSi(OR)3]. Both the hydrophobicity and hydrolytic lability of these silicates can be (independently) controlled by choice of the alkyl group (R). The synthesis, structural characterization, hydrolytic reactivity, and in vitro cytotoxicity against the MDA-MB-231 breast cancer cell line of most of these derivatives are described. We envision that the greater hydrophobicity of these silicates (vis-à-vis PTX or DTX itself) should be advantageous from the perspective of preparation of stable aqueous dispersions of amphiphilic block-copolymer-based nanoparticle formulations.
The First Tri- and Tetraalkoxysilanes with Four Different Substituents
Clausen, Rasmus P.,Bols, Mikael
, p. 4457 - 4464 (2007/10/03)
Unsymmetrically substituted tri- and tetraalkoxysilanes were surprisingly found to be configurationally stable and easy to prepare. It was found that compounds of type MeSi(OR)2(OR′), MeSi- (OR)(OR′)(OR″), Si(OR)2(OR′)2, Si(OR)2(OR′)(OR″), Si(OR)3(OR′), and even Si(OR)(OR′)(OR″)(OR*) could be obtained by sequential addition of a variety of chiral and achiral alcohols to methyltrichlorosilane or tetrachlorosilane in the presence of pyridine. In the case of MeSi(OR)(OR′)(OR″) and Si(OR)(OR′)(OR″)(OR*), two types of compounds that have never been prepared before, were obtained in good yield.
