18765-58-7Relevant academic research and scientific papers
19-Hydroxy-PGI2 compounds
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, (2008/06/13)
Prostacyclin and prostacyclin-type derivatives having a 19-hydroxy feature are disclosed, including processes for preparing them and the appropriate intermediates. The compounds are useful for pharmacological purposes such as inhibition of blood platelate aggregation.
2-Decarboxy-2-hydroxymethyl-19-hydroxy-PG1 analogs
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, (2008/06/13)
Prostaglandin derivatives having a 19,20-didehydro, a 19-hydroxy, or a 19-keto feature are disclosed, including processes for preparing them and the appropriate intermediates. A typical 19-hydroxy compound of this invention is 19-hydroxy-19-methyl-PGF2α, methyl ester, represented by the formula STR1
Bicyclic lactones
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, (2008/06/13)
Process for preparing bicyclic lactone acrylic aldehydes and ketones of the formula STR1 wherein "n" is one or 2, wherein R1, is hydrogen, methyl, or ethyl, and wherein R4 is hydrogen or a blocking group; and those aldehydes, ketones, and intermediates prepared therein. The aldehydes and ketones are useful intermediates in preparing prostaglandins and analogs having pharmacological utility.
