187655-75-0

Basic information

• Product Name: N-p-toluenesulfonyl-4-iodoindole-3-carbaldehyde
• Synonyms: N-p-toluenesulfonyl-4-iodoindole-3-carbaldehyde
• CAS NO: 187655-75-0
• Molecular Weight: 425.247
• Mol File: 187655-75-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-p-toluenesulfonyl-4-iodoindole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: N-p-toluenesulfonyl-4-iodoindole-3-carbaldehyde(187655-75-0)
• EPA Substance Registry System: N-p-toluenesulfonyl-4-iodoindole-3-carbaldehyde(187655-75-0)

Safety Data

• Hazardous Substances Data: 187655-75-0(Hazardous Substances Data)

Upstream product

• 50562-79-3 1-(4-tolylsulfonyl)indole-3-carboxaldehyde 

Relevant articles and documents

Transient Directing Group Strategy as a Unified Method for Site Selective Direct C4-H Halogenation of Indoles

A unified method for direct C4-H halogenation of indoles has been accomplished with the assistance of anthranilic acids as suitable transient directing groups. Exclusive site selectivity (one out of five potential reactive sites) as well as good functional group tolerance was obtained to install three kinds of halogen atoms (Cl, Br and I, respectively) by using inexpensive N-halosuccinimides (NXS) as halogen sources under mild conditions. Taking advantage of the rich functional groups in the product, a diversity of nitrogen-containing heterocycles were facily constructed via one-step late-stage derivations.

A convenient preparation of 4-iodoindoles from indoles: Application to the chemical synthesis of hapalindole alkaloids

4-Iodoindoles were synthesized via regioselective chloromercuration and subsequent iodination of a series of N-p-toluenesulfonyl indoles bearing a variety of substituents at the 3-position. This procedure allows rapid access to 3,4-dihaloindoles which may be used as synthetic precursors to indole alkaloids.