187663-95-2Relevant academic research and scientific papers
Synthesis of α-necrodol: Unexpected formation of a cyclopropene
Taber, Douglass F.,Yu, Han
, p. 1687 - 1690 (1997)
Significant 1,3-induction in intramolecular alkylidene C-H insertion is reported. Thus, exposure of ketone I to the lithium salt of (trimethylsilyl)diazomethane provides a 2.4:1.0 ratio of IIa and IIIa, which are deprotected to α-necrodol IIb and the epimeric IIIb. The 1,3-insertion product cyclopropene IV was also formed.
