187679-81-8

Basic information

• Product Name: 2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-
• Synonyms: 2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-
• CAS NO: 187679-81-8
• Molecular Formula: C11H13NOS
• Molecular Weight: 207.29
• Mol File: 187679-81-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-(187679-81-8)
• EPA Substance Registry System: 2(1H)-Quinolinethione, 3,4-dihydro-6-methoxy-1-methyl-(187679-81-8)

Safety Data

• Hazardous Substances Data: 187679-81-8(Hazardous Substances Data)

Usage

Class of organic compounds

Quinolines and derivatives

Type of receptor

Serotonin receptor antagonist

Specific receptor subtype

5-HT2 receptor

Potential use

Treatment of psychiatric and neurological disorders

Role in the brain

Modulation of dopamine and other neurotransmitter release

Research applications

Understanding the role of serotonin in physiological and pathological conditions

Pharmacological properties

Demonstrated potential for further study and development.

Upstream product

• 187679-62-5 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline 
• 19172-47-5 Lawessons reagent 

Downstream Products

• 187680-06-4 7-methoxy-1-methyl-2-thioxo-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

SUBSTITUTED BENZOLACTAM COMPOUNDS

This invention relates to compounds of general formula (I): or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R, R, and R are defined herein. This invention also relates to compounds of formula (I), depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S)-2-phenylpiperidine-3-yl may optionally be substituted with fluoro; Q is oxygen and is double bonded to the carbon atom to which it is attached, X is methoxy or ethoxy, R is hydrogen, methyl or halo-C1-C2 alkyl, W is methylene, ethylene or vinylene; R and R are independently hydrogen or methyl, or one of R or R may be hydroxy, when W is ethylene, R and R are both methyl, when W is methylene, and R and R are both hydrogen, when W is vinylene. The invention is further directed to methods of treating various CNS and other disorders using said compounds and pharmaceutical compositions thereof.

Substituted benzolactam compounds as substance P antagonists

Compounds of the formula are effective for the treatment of conditions in mammals which require inhibition of the action of substance P.