187724-92-1

Basic information

• Product Name: ethyl 4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate
• CAS NO: 187724-92-1
• Molecular Formula: C₁₅H₁₃N₃O₃
• Molecular Weight: 283.282
• Mol File: 187724-92-1.mol
• Article Data: 1

Chemical Properties

• Density: 1.372g/cm³
• Refractive Index: 1.675
• CAS DataBase Reference: ethyl 4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate(187724-92-1)
• EPA Substance Registry System: ethyl 4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate(187724-92-1)

Safety Data

• Hazardous Substances Data: 187724-92-1(Hazardous Substances Data)

Upstream product

• 187724-91-0 ethyl 2-amino-5-(4-(ethoxycarbonyl)phenyl)-1H-pyrrole-3-carboxylate 
• 77287-34-4 formamide 
• 81590-55-8 ethyl 4-(2-bromoacetyl)benzoate 

Downstream Products

• 187724-93-2 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoic acid ethyl ester 

Relevant articles and documents

Synthesis and cholinesterase inhibition activity of new pyrrolopyrimidine derivatives

Cholinesterase plays a vital role in the decline of cholinergic transmission and thus can contribute to the development of Alzheimer's disease (AD). Thus, compounds that can inhibit acetylcholinesterase (AChe) and butyrylcholinesterase (BuChe) are the potential drugs for the treatment of AD. A series of novel pyrrolopyrimidine derivatives was synthesized and evaluated for their inhibitory activity against cholinesterase by Ellman method. Among the ten newly synthesized compounds, 4-(4-((4-(difluoromethoxy)phenyl)amino)-7H-pyrrolo [2,3-d]pyrimidin-6-yl)benzoate was the most potent molecule identified with the IC50 values of 18 μM and 17 uM on AChe and BuChe respectively.